Laboratory testing is used across all care settings and specialties for screening, diagnosis and disease management, and has a significant impact on care outcomes and costs. While hospitals work to improve the health of their patients and communities, they continue to be confronted with financial pressures stemming from the COVID-19 pandemic, such as lost revenue and increased costs associated with labor and treating COVID patients. Hospital laboratory leaders tasked with identifying cost savings may come up short by focusing on traditional, often-used methods such as price reductions, improved contracting and inventory management. Shifting your focus to demand management can be an effective way to secure laboratory cost reductions while supporting physicians, improving outcomes and remaining abreast of emerging science.